PROFIL ANEMIA DAN PENANDA INFLAMASI SEBAGAI DETEKSI DINI PENYAKIT PENYERTA PADA ANAK-ANAK STUNTING DI BAWAH UMUR DUA TAHUN DI KABUPATEN SUKABUMI
DOI:
https://doi.org/10.34147/crj.v11i01.390Kata Kunci:
profil anemia, Penanda Inflamasi, stuntingAbstrak
Stunting adalah salah satu masalah kekurangan gizi kronik di kalangan anak-anak umur di bawah dua tahun (Baduta). Pemerintah Indonesia telah melakukan berbagai upaya pemberian makanan tambahan dan obat tambahan, tetapi belum memberikan hasil yang optimal. Penelitian ini bertujuan untuk menguraikan profil anemia dan penanda inflamasi pada anak di bawah dua tahun yang mengalami stunting. Penelitian ini merupakan penelitian deskriptif cross-sectional, didapatkan 85 anak baduta stunting dengan berbagai kemungkinan penyakit yang mendasarinya dengan teknik pengambilan data cluster sample dan consecutive sample. Penelitian dilakukan di Laboratorium Rumah Sakit Umum Daerah (RSUD) Palabuhanratu Kabupaten Sukabumi dengan sampel darah yang diperoleh dari anak-anak stunting di wilayah Palabuhanratu dan Cisaat. Pengumpulan data dengan cara wawancara, pengukuran antropometri, pemeriksaan hematologi dan penanda inflamasi, pemeriksaan kadar zat besi, serta kadar ferritin. Hasil penelitian: dugaan Thalassemia (20%), anemia defisiensi zat besi (17%), anemia penyakit kronis (12%), dugaan TB (10%), dugaan Inflammatory Bowel Diseases (14%), dugaan proctocolitis allergy (10%), dugaan Helminthiasis (11%), dan infeksi bakteri lainnya (7%). Terdapat berbagai macam penyebab anemia dan kecurigaan penyakit penyerta pada anak stunting. Pemeriksaan profil anemia dan penanda inflamasi dianjurkan di fasilitas kesehatan primer untuk menentukan jenis anemia dan penyakit komorbid pada baduta stunting. Alat hematology analyzer dan kimia analyzer perlu disediakan di fasilitas kesehatan primer.
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Referensi
Abdullah A. The Double Burden of Undernutrition and Overnutrition in Developing Countries: an Update. Curr Obes Rep. 2015 Sep;4(3):337-49. DOI: 10.1007/s13679-015-0170-y
Addo OY, Stein AD, Fall CH, Gigante DP, Guntupalli AM, Horta BL, et al. Maternal height and child growth patterns. J Pediatr. 2013 Aug;163(2):549-54. DOI: 10.1016/j.jpeds.2013.02.002
Cursi L, Lancella L, Mariani F, Martino L, Leccese B, Di Giuseppe M, et al. Monocyte-to-lymphocyte, neutrophil-to-lymphocyte and neutrophil-to-monocyte plus lymphocyte ratios in children with active tuberculosis: A multicentre study. Acta Paediatr. 2023 Nov;112(11):2418-25. DOI: 10.1111/apa.16932
Domnicu AE, Boia ER, Mogoi M, Manea AM, Marcovici TM, Marginean O, et al. The Neutrophil-to-Lymphocyte Ratio (NLR) Can Predict Sepsis's Presence and Severity in Malnourished Infants-A Single Center Experience. Children (Basel). 2023 Sep 28;10(10). DOI: 10.3390/children10101616.
Global Hunger Index 2023 [database on the Internet]. World Health Organization. 2023 [cited September 19, 2024]. Available from: https://www.globalhungerindex.org/pdf/en/2023/Indonesia.pdf.
Gysi S, Doulberis M, Legeret C, Kohler H. The Role of the Pediatric Yorkhill Malnutrition Score (PYMS), Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Malnutrition Prediction of Hospitalized Children. Children (Basel). 2022 Sep 13;9(9).
DOI: 10.3390/children9091378.
Health IMo. Decree of The Ministry of Health of The Republic Indonesia ( (Number HK.01.07/MENKES/1928/2022 ). In: Health Mo, editor. Jakarta: Ministry of Health; 2022. p. 1-52.
Kemenkes. Pocket Book: Indonesian Nutritional Status Survey (SSGI) 2022. Jakarta: Ministry of Health of Indonesia Republic; 2022. https://repository.badankebijakan.kemkes.go.id/id/eprint/4855/
Kissling M, Fritschi N, Baumann P, Buettcher M, Bonhoeffer J, Naranbhai V, et al. Monocyte, Lymphocyte and Neutrophil Ratios - Easy-to-Use Biomarkers for the Diagnosis of Pediatric Tuberculosis. Pediatr Infect Dis J. 2023 Jun 1;42(6):520-7. DOI: 10.1097/INF.0000000000003901
Maskoen AM, Reniarti L, Sahiratmadja E, Sisca J, Effendi SH. Shine & Lal index as a predictor for early detection of beta-thalassemia carriers in a limited resource area in Bandung, Indonesia. BMC Med Genet. 2019 Aug 9;20(1):136. DOI: 10.1186/s12881-019-0868-x
Ma TY, Iwamoto GK, Hoa NT, Akotia V, Pedram A, Boivin MA, et al. TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation. Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3). DOI: 10.1152/ajpgi.00173.2003
Nacaroglu HT, Bahceci Erdem S, Durgun E, Karaman S, Baris Erdur C, Unsal Karkmer CS, et al. Markers of inflammation and tolerance development in allergic proctocolitis. Arch Argent Pediatr. 2018 Feb 1;116(1). DOI: 10.5546/aap.2018.eng.e1
Nations U. Transforming Our World: The 2030 Agenda for Sustainable Development. United Nations; 2017. p. 1-36. https://sdgs.un.org/2030agenda
Perez-Machado MA, Ashwood P, Thomson MA, Latcham F, Sim R, Walker-Smith JA, et al. Reduced transforming growth factor-beta1-producing T cells in the duodenal mucosa of children with food allergy. Eur J Immunol. 2003 Aug;33(8):2307-15. DOI: 10.1002/eji.200323308
Pradana Putri A, Rong JR. Parenting functioning in stunting management: A concept analysis. J Public Health Res. 2021 Apr 14;10(2). DOI: 10.4081/jphr.2021.2160
Pratiwi IGAPE, Irawan R, Ugrasena IDG, Faizi M. Vitamin D, insulin-like growth factor-1, and stunting in children with transfusion-dependent thalassemia. Paediatr Indones. 2022;62:98-103. DOI: https://doi.org/10.14238/pi62.2.2022.98-103
Prendergast AJ, Humphrey JH. The stunting syndrome in developing countries. Paediatr Int Child Health. 2014 Nov;34(4):250-65. DOI: 10.1179/2046905514Y.0000000158
TNP2K. 100 Priority Districts/Cities for Stunting Intervention. Edisi ke-1. Jakarta: TNP2K(Poverty Reduction Acceleration Team)-Unit Komunikasi;2017. hlm. 1-38. https://kms.kemenkopm.go.id/
Vehapoglu A, Ozgurhan G, Demir AD, Uzuner S, Nursoy MA, Turkmen S, et al. Haematological indices for differential diagnosis of Beta thalassemia trait and iron deficiency anaemia. Anemia. 2014;2014:576738. DOI: 10.1155/2014/576738.
Zahmatkesh A, Sohouli MH, Hosseini SME, Rohani P. The role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in the diagnosis and severity of inflammatory bowel disease in children. Eur J Pediatr. 2023 Sep;182(9):4263-70. DOI: 10.1007/s00431-023-05110-0
Sabin FR, Sugiyama S, Kindwall JA, Cunningham RS. The role of the monocyte in tuberculosis. B Johns Hopkins Hosp. 1925;4:231-80.
Van Vranken M. Evaluation of microcytosis. Am Fam Physician. 2010 Nov 1;82(9):1117-22. PMID: 21121557
Wahidiyat PA, Sari TT, Rahmartani LD, Iskandar SD, Pratanata AM, Yapiy I, et al. Thalassemia in Indonesia. Hemoglobin. 2022 Jan;46(1):39-44. DOI: 10.1080/03630269.2021.2023565
WHO. Global Nutrition Targets 2025: Stunting Policy Brief. World Health Organization (WHO); 2014. p. 1-12. https://www.who.int/publications/i/item/WHO-NMH-NHD-14.3
WHO. Levels and trends in child malnutrition. In: Estimates JCM, editor. 2023 ed. Geneva: World Health Organization; 2023. p. 1-32.https://www.who.int/publications/i/item/9789240073791
WHO. The Asia-Pacific Perspective: Redefining Obesity and Its Treatment. In: Obesity IIAFTS, editor. Australia: Health Communications Australia; 2000. p. 17. https://iris.who.int/bitstream/handle/10665/206936/0957708211_eng.pdf
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